Ways to support methylation

Updated: Aug 3, 2021

Methylation is a biological process in our body that helps to support many vital functions relating to our cardiovascular, neurological, reproductive& detoxification systems as well as the production of DNA. However, when methylation isn't functioning optimally these areas may become compromised. It can affect everyone differently and that's why its good to understand what it is and how it may be affecting you.

MTHFR Explained

To understand methylation we need to touch on the gene MTHFR. MTHFR provides the body with instructions for making the enzyme of the same name MTHFR via methylation.

But don't let the name double up confuse you - what you need to know is that when you eat foods containing folate the MTHFR gene conveniently converts them into the active form, methyl-folate through the process of methylation.

Those with a defective MTHFR gene can have an impaired ability to produce the MTHFR enzyme.

This can make it more difficult to break down and eliminate not only synthetic folic acid but also other substances, such as heavy metals, xenobiotics and prescription drugs.

What is the methylation pathway?

Think of methylation as an on/off switch. If methyl-folate is not present, this methylation process switches off, resulting in a multitude of symptoms.

What is methylation responsible for?

o Metabolism and excretion of drugs,

o The creation of neurotransmitters and hormones including dopamine, histamine, melatonin and oestrogen to facilitate their excretion

o The synthesis and repair of myelin proteins

o Energy production

o Mobilisation and elimination of fats and cholesterol

o Required so that DNA can modify the transcription of a gene

Conditions associated with a MTHFR gene mutation

Research has shown an association between MTHFR mutation and many severe health problems including:


o Autism

o Autoimmune diseases

o Thyroid issues

o Cardiovascular disease

o Chronic fatigue

o Sleep disorders

o Anxiety

o Migraine

o Depression

o Colon cancer

o Digestive issues, including IBS

o Hormonal issues, including PCOS

o Schizophrenia

o Recurrent miscarriage

Common symptoms seen in people with impaired methylation:

o Fatigue

o Insomnia

o Depression

o Addiction

o Obsessive-compulsive disorders

o Seasonal allergies

o Delusion

o Low threshold for pain

o Digestive issues

o High libido

o Self-motivation

o Perfectionism

o Strong will

MTHFR Variations - C677T & A1298C

There are many different variations of MTHFR gene mutation, however the two most researched and most common mutations that can occur are C677T and A1298C. All mutations stem from a variation in our genes passed on from each parent.

The most common forms of MTHFR mutation involve various combinations of these genes being passed on from each parent:

o Homozygous: the same gene passed on from both parents

o Heterozygous: a gene mutation is passed from one parent, with the other parent passing on a healthy gene

o Compound heterozygous: one parent passes on one type of gene mutation, while the other parent passes on another type of gene mutation

6 ways to support methylation

There are many active steps you can take to make up for what your body lacks. Here are some of my favourite tips:

1. Consume folate and vitamin B12 containing foods